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Tomar, Dhanendra
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overview Current Projects: Mitochondrial Ultrastructural Remodeling and Inter-Organelles Crosstalk: We aim to identify the molecular determinants, and signaling events associated with mitochondrial contact sites and mitochondrial membranes architecture. Protein Quality Control: Our research aims to identify the molecular determinants of the mitochondrial protein quality control mechanisms and delineate the associated molecular events that lead to disease onset. Calcium signaling and mitochondrial ionic homeostasis: We aim to identify the new regulators and regulatory events associated with mitochondrial calcium-sensing/flux and their role in animal physiology using protein biochemistry, high-end imaging-based approaches, and genetic manipulations. Cardiac Physiology & Metabolism: We aim to characterize the molecular regulators and events involved in cardiac physiology and metabolism using mouse genetics and physiology-based in vivo methods.
One or more keywords matched the following items that are connected to Tomar, Dhanendra
Item TypeName
Concept Humans
Concept Biofilms
Concept Receptors, Adrenergic, beta-1
Concept Bacterial Proteins
Concept Calcium-Binding Proteins
Concept Binding Sites
Concept JC Virus
Concept Animals
Concept Aged
Concept Proto-Oncogene Proteins c-bcl-2
Concept Statistics as Topic
Concept Protein Biosynthesis
Concept Mice, Knockout
Concept Saccharomyces cerevisiae
Concept Blotting, Western
Concept Mice
Concept Receptors, Adrenergic, beta
Concept Mice, Inbred C57BL
Concept Blood Platelets
Concept Mice, Transgenic
Concept Protein Binding
Concept I-kappa B Kinase
Concept Staphylococcus aureus
Concept Anti-Bacterial Agents
Concept DNA-Binding Proteins
Concept NF-kappa B
Concept Brain
Concept Methylene Blue
Concept Butylene Glycols
Concept rho GTP-Binding Proteins
Concept HIV-1
Concept Mice, Nude
Concept NF-E2-Related Factor 2
Concept Rats
Concept African Americans
Concept Rats, Wistar
Concept Breast Neoplasms
Concept Middle Aged
Concept Zebrafish
Concept Mice, Mutant Strains
Academic Article SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics.
Academic Article Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model.
Academic Article Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Academic Article Novel BAG3 Variants in African American Patients With Cardiomyopathy: Reduced ß-Adrenergic Responsiveness in Excitation-Contraction.
Academic Article Mitochondrial Protein Quality Control Mechanisms.
Academic Article Context-Dependent Regulation of Nrf2/ARE Axis on Vascular Cell Function during Hyperglycemic Condition.
Academic Article Nicotinamide riboside kinase-2 alleviates ischemia-induced heart failure through P38 signaling.
Academic Article Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation.
Academic Article MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress.
Academic Article Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.
Academic Article Mitochondrial dysfunction in human primary alveolar type II cells in emphysema.
Academic Article The relationship between DJ-1 and S100A8 in human primary alveolar type II cells in emphysema.
Academic Article The role of DJ-1 in human primary alveolar type II cell injury induced by e-cigarette aerosol.
Academic Article Blockade of MCU-Mediated Ca2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation.
Academic Article Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation.
Academic Article Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy.
Academic Article FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation.
Academic Article Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals.
Academic Article MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca2+ Stress.
Academic Article TRIM8 regulated autophagy modulates the level of cleaved Caspase-3 subunit to inhibit genotoxic stress induced cell death.
Academic Article Methylene blue counteracts cyanide cardiotoxicity: cellular mechanisms.
Academic Article Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, ß-adrenergic insensitivity, and increased apoptosis.
Academic Article Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function.
Academic Article Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth.
Academic Article Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity.
Academic Article hsa-miR-4485 regulates mitochondrial functions and inhibits the tumorigenicity of breast cancer cells.
Academic Article Structural Insights into Mitochondrial Calcium Uniporter Regulation by Divalent Cations.
Academic Article MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics.
Academic Article BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes.
Academic Article TRIM4; a novel mitochondrial interacting RING E3 ligase, sensitizes the cells to hydrogen peroxide (H2O2) induced cell death.
Academic Article SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore.
Academic Article NLRX1 acts as tumor suppressor by regulating TNF-a induced apoptosis and metabolism in cancer cells.
Academic Article TRIM family proteins: emerging class of RING E3 ligases as regulator of NF-?B pathway.
Academic Article TRIM13 regulates ubiquitination and turnover of NEMO to suppress TNF induced NF-?B activation.
Academic Article Antiviral signaling protein MITA acts as a tumor suppressor in breast cancer by regulating NF-?B induced cell death.
Academic Article TRIM13 regulates caspase-8 ubiquitination, translocation to autophagosomes and activation during ER stress induced cell death.
Academic Article Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene, is involved in positive regulation of TNF induced NF-?B pathway.
Academic Article The leucine aminopeptidase of Staphylococcus aureus is secreted and contributes to biofilm formation.
Academic Article TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells.
Grant Impact of mitochondrial structure on cellular homeostasis and hepatic injury
Academic Article TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy.
Grant Mitochondrial inter-membrane space protein quality control in Barth syndrome-associated cardiomyopathy
Academic Article Nicotinamide riboside kinase-2 regulates metabolic adaptation in the ischemic heart.
Academic Article MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial Ca2+ uniporter channel.
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